I stayed at Galleria 10 for 4 nights and was really happy with my accommodations. I paid 1855 baht per night booking right through their website. I think the hotel is well priced coming in a bit cheaper than some of ritzier places like Grand Swiss, Dawin, or Phachara. I haven't stayed at the more expensive places but I have stayed at a cheaper place and can say Galleria is worth the money.
My room was very comfortable and inviting. The shower was best I've had in Thailand, the bed was big and comfy, had a nice view of the city on the 6th floor (which i requested), and the safety deposit box was big enough for my 15" laptop. They have a nice system where you flick on a light for Do Not Disturb, or Request Room Clean. This way they don't bug you all the time about it.
The pool is definitely too small but not much can be done about that, still nice for a dip after a long day. The roof area is really nice with lots of little spots to chill and zero pressure from the restaurant staff. I would bring up my own beer and food all the time and they never said a word.
The place is definitely guest friendly and never said a word about my LB's or girls. It's geared more towards regular tourists so the only weirdness you will get is from them of course. The staff are lovely people. I find I'm torn on whether i prefer a normal hotel that is ok with the guests or a hotel geared towards mongering (basically anything on Soi 4). With Galleria being on Soi 10 it was nice to escape the madness and relax for a while, make eyes with the Swedish tourist girls and be amused by the couples who seem miserable half the time. True enough that the elevator requires a room key so if you have a LB come to see you, you essentially have to go down to the lobby and declare your everlasting love for ladyboys to everyone there. Some of us are more ready for that than others.
I would say Galleria 10 is a great option for those newer to the game who want to get in on the shallow end and also need to save a bit of cash. I'm not certain I need to spend more for the nicer places as I felt all my needs were met here. The only thing I would maybe prefer is to be a bit closer to Nana Plaza. I tried a cheaper place for the last night (SM Grande Residence) and it was definitely not worth it. Maybe it was just the place but I felt it better to spend a bit more then to have a bad room you are embarrassed to take the girls.